5 Stages Every Woman Over 40 Goes Through (Backed by Neuroscience)
Resetter PodcastPublished on November 24, 2025
Summary authored by editor@wellifi.com
TLDR Summary
Dr. Mindy Pelz's book, <em>Age Like a Girl</em>, explores the neurochemical changes during menopause and offers lifestyle strategies to empower women. By understanding and addressing these changes, women can navigate menopause more effectively and embrace this transformative phase of life.
Key Points
- Menopause involves significant neurochemical changes influenced by estrogen.
- Key neurochemicals include dopamine, serotonin, acetylcholine, glutamate, GABA, BDNF, oxytocin, melatonin, and insulin.
- Lifestyle strategies such as storytelling, movement, and fasting can help restore neurochemical balance.
- A primal menopausal diet focusing on tubers and reducing ultraprocessed foods supports hormonal health.
- Embracing menopause can lead to personal transformation and empowerment.
Understanding the Neurochemical Changes in Menopause: A Guide to Thriving
Menopause is often perceived as a daunting phase in a woman's life, filled with physical and emotional challenges. However, Dr. Mindy Pelz presents a refreshing perspective in her new book, Age Like a Girl, where she emphasizes the neurochemical changes that occur during this transition and how lifestyle adjustments can help women thrive during this time.
The Girl Gang: Neurochemicals Affected by Estrogen
Dr. Pelz introduces the concept of the "girl gang," which includes nine neurochemicals that are directly influenced by estrogen, as well as three honorary members that, while not neurochemicals themselves, play significant roles due to estrogen's impact. Understanding these neurochemicals can empower women to take charge of their mental and emotional health during menopause.
Core Neurochemicals
- Dopamine: The motivation molecule, essential for driving action and pleasure.
- Serotonin: The mood stabilizer that helps maintain a sense of well-being.
- Acetylcholine: Crucial for memory, attention, and alertness.
- Glutamate: An excitatory neurotransmitter involved in learning and memory.
- GABA: The calming neurotransmitter that balances glutamate.
- Brain-Derived Neurotrophic Factor (BDNF): Known as "miracle grow for the brain," it supports new memory and learning.
- Oxytocin: The bonding hormone that fosters connections with others.
- Melatonin: Regulates sleep and circadian rhythms.
- Insulin: Affects blood sugar levels and metabolism.
Honorary Members
- Collagen
- Creatine
- Glucose
Strategies to Boost Neurochemicals
Dr. Pelz emphasizes lifestyle tools that can help restore the balance of these neurochemicals without the need for expensive treatments. Here are some of the key strategies:
Memory Enhancement
- Engage in storytelling to stimulate acetylcholine and activate memory recall.
- Practice movement daily to boost BDNF levels.
- Incorporate longer fasting periods to enhance memory retention.
Mood Boosting
- Seek novelty and new experiences to increase dopamine levels.
- Spend time outdoors to boost serotonin through sunlight exposure.
- Engage in meaningful social interactions to enhance oxytocin.
Dietary Considerations
Dr. Pelz suggests a shift in dietary focus to support hormonal changes and neurochemical balance:
- Emphasize a primal menopausal diet, highlighting tubers that are high in magnesium and low on the glycemic index.
- Reduce intake of ultraprocessed foods which can exacerbate excitatory neurotransmitter levels.
- Consider collagen and creatine supplementation, especially for those not consuming sufficient protein.
Conclusion: Embracing Change
Menopause is not just an end but a beginning—a time to embrace new possibilities and transformations. By understanding the neurochemical changes and implementing lifestyle adaptations, women can navigate this phase with grace and empowerment. Dr. Pelz's Age Like a Girl serves as a guide for women looking to harness the power of their bodies during menopause and emerge stronger than ever.
