Dr. Fiona McCulloch shares about Insulin, Genetics & Why PCOS Symptoms Get Worse After 30
Dr. Jolene BrightenPublished on November 20, 2025
Summary authored by editor@wellifi.com
TLDR Summary
PCOS is a complex endocrine disorder that requires a multifaceted approach to management, including lifestyle changes, nutritional support, and understanding hormonal imbalances. Dr. Fiona McCulla emphasizes the importance of individualized care, recognizing the role of insulin resistance, and the need for ongoing attention to women's health throughout their lifespan.
Key Points
- PCOS is an endocrine disorder characterized by hormonal imbalances, primarily elevated testosterone.
- Insulin resistance affects approximately 70% of women with PCOS and plays a significant role in symptom severity.
- Testing fasting insulin levels is crucial for understanding insulin resistance.
- Nutritional and lifestyle interventions, including increased protein intake and exercise, are vital for managing PCOS.
- Supplements like inositol and berberine can be beneficial for hormone regulation and insulin sensitivity.
- PCOS does not resolve with menopause; ongoing management is necessary.
- Genetic and environmental factors must be considered in treatment strategies.
Understanding PCOS: Insights from Dr. Fiona McCulla
Polycystic Ovary Syndrome (PCOS) is often misunderstood as merely a reproductive issue, but it is fundamentally an endocrine condition characterized by hormone imbalances. In this blog post, we will explore the insights shared by Dr. Fiona McCulla, a leading naturopathic doctor specializing in PCOS, as she discusses the complexities of this condition, its implications, and potential management strategies.
What is PCOS?
PCOS, despite its name, involves more than just ovarian cysts; it is primarily an endocrine disorder marked by elevated levels of testosterone and other androgen hormones, leading to a variety of symptoms and associated health risks, including:
- Irregular menstrual cycles
- Acne
- Unwanted hair growth (hirsutism)
- Hair loss
- Increased risk of type 2 diabetes and heart disease
- Potential links to mental health disorders
Hormonal Imbalances and Their Sources
Dr. McCulla emphasizes that testosterone in women with PCOS originates not only from the ovaries but also from the adrenal glands. The adrenal glands can produce dehydroepiandrosterone sulfate (DHEAS), which can convert to testosterone, affecting overall hormone levels.
Identifying the Source of Androgen Production
To differentiate whether excess androgens are coming from the ovaries or adrenal glands, blood tests measuring DHEAS and testosterone can be conducted. If DHEAS levels are high, it likely indicates an adrenal source of androgen production.
The Role of Insulin Resistance in PCOS
Insulin resistance is prevalent in approximately 70% of women with PCOS. It contributes to the severity of many symptoms and conditions associated with PCOS, including hormonal imbalances. Dr. McCulla recommends testing fasting insulin levels to get a clearer picture of insulin resistance, as glucose levels alone may not provide sufficient insight.
Nutrition and Lifestyle Interventions
Effective management of PCOS often includes dietary changes, such as:
- Increasing protein intake (aim for at least 90 grams per day)
- Incorporating healthy carbohydrates to stabilize blood sugar levels
- Prioritizing fiber-rich foods for gut health
- Engaging in regular physical activity, particularly strength training
Supplement Recommendations
Dr. McCulla highlights the importance of certain supplements for managing PCOS:
- Inositol: Helps regulate LH and FSH levels, crucial for ovarian function.
- Berlberine: Assists with insulin resistance and has antifungal properties.
- Chaste Tree Berry (Vitex): Can help balance prolactin levels without negatively impacting hormonal function.
The Connection Between PCOS and Mental Health
Women with PCOS are at a higher risk for mental health issues, including anxiety and depression. It’s vital for healthcare providers to acknowledge this link and offer holistic support that addresses both physical and mental well-being.
Addressing PCOS Through the Lifespan
PCOS does not simply resolve with menopause. While ovarian function ceases, adrenal production of hormones continues and can lead to persistent symptoms. Dr. McCulla advises that maintaining a healthy lifestyle can alleviate some menopausal symptoms linked to PCOS.
Genetic and Environmental Factors
New research points to the importance of understanding genetic predisposition and environmental influences on PCOS. The condition can also manifest differently across various ethnic and cultural backgrounds, necessitating a personalized approach to treatment.
Conclusion
PCOS is a multifaceted condition that requires a comprehensive understanding and a personalized approach to management. By addressing hormonal imbalances, insulin resistance, and lifestyle factors, women can effectively manage their symptoms and improve their overall health. Dr. Fiona McCulla’s insights provide valuable guidance for navigating the complexities of PCOS, emphasizing the importance of individualized care and ongoing research.
Key Takeaways
- PCOS is an endocrine disorder characterized by hormonal imbalances, primarily elevated testosterone.
- Insulin resistance affects approximately 70% of women with PCOS and plays a significant role in symptom severity.
- Testing fasting insulin levels is crucial for understanding insulin resistance.
- Nutritional and lifestyle interventions, including increased protein intake and exercise, are vital for managing PCOS.
- Supplements like inositol and berberine can be beneficial for hormone regulation and insulin sensitivity.
- PCOS does not resolve with menopause; ongoing management is necessary.
- Genetic and environmental factors must be considered in treatment strategies.
TLDR Summary
PCOS is a complex endocrine disorder that requires a multifaceted approach to management, including lifestyle changes, nutritional support, and understanding hormonal imbalances. Dr. Fiona McCulla emphasizes the importance of individualized care, recognizing the role of insulin resistance, and the need for ongoing attention to women's health throughout their lifespan.
Authors
- Dr. Fiona McCulla
- Dr. Jolene Brighton
