Podcast: More on NAD+ Boosting Supplements
NutritionFacts.orgPublished on October 16, 2025
Summary authored by editor@wellifi.com
TLDR Summary
NAD+ boosting supplements may be linked to serious health risks, including the exacerbation of infections and cancer. Instead, natural methods such as exercise and a diet rich in flavonoids are recommended for enhancing NAD+ levels safely.
Key Points
- NAD+ boosting supplements may have minor side effects but pose serious health risks.
- Potential adverse effects include exacerbation of infections and promotion of cancer cell growth.
- Natural methods to boost NAD+ include exercise and a diet rich in flavonoids.
- Regular exercise can significantly increase NAMPT levels and improve overall health.
- Certain foods, such as apples and onions, can help maintain NAD+ levels.
Natural Approaches to Boosting NAD+ and Health
Have you ever wondered if there are more natural ways to lower your high blood pressure, guard against Alzheimer’s, lose weight, and feel better? Well, it turns out there is! Welcome to the Nutrition Facts Podcast. I’m your host, Dr. Michael Greger. In today’s episode, we wrap up our series on the enzyme NAD+ and explore the complexities surrounding NAD+ boosting supplements.
The Cautionary Tale of NAD+ Boosting Supplements
While many NAD+ precursors, such as NAM, NR, and NMN, are marketed for their purported benefits, most reported side effects are relatively minor, including diarrhea, nausea, rashes, hot flashes, and leg cramps. However, there are some serious concerns about their effects on health.
Potential Risks of NAD+ Boosters
- Exacerbation of infections by Haemophilus bacteria, which rely on host NAD+ levels.
- Potential immune system overreaction in cases of autoimmune diseases.
- Promotion of cancer cell growth and spread in cancer patients.
For example, the enzyme NAMPT, responsible for NAD+ synthesis, is often elevated in inflamed tissues and cancerous tumors. Studies suggest that NAD+ boosting could worsen conditions like rheumatoid arthritis or even accelerate cancer progression.
Natural Ways to Boost NAD+
Instead of relying solely on supplements, there are natural methods to enhance NAD+ levels in the body:
1. Activate NAD+ Synthesizing Enzymes
One effective way to increase NAD+ is through the activation of the enzyme NAMPT. Research shows that exercise significantly boosts NAMPT levels—sedentary individuals who began an exercise program saw a 127% increase in NAMPT levels within three weeks.
2. Exercise Regularly
Exercise not only increases NAMPT but also enhances muscle NAD+ levels and sirtuin activity, which supplements often fail to achieve.
3. Conserve NAD+
Prevent excessive consumption of NAD+ by limiting the activation of enzymes like PARP-1 and CD38, which deplete NAD+ levels. Maintaining a healthy diet low in oxidative stress can help mitigate this loss.
Dietary Sources for NAD+ Boosting
Certain foods are rich in flavonoids that can inhibit CD38 and PARP-1 and help maintain NAD+ levels:
- Proanthocyanidins: Found in apples, plums, wild blueberries, and cinnamon.
- Quercetin: High in onions, which can significantly boost quercetin levels in the blood.
- Luteolin: Present in oregano and radicchio.
These compounds can help preserve NAD+ levels while offering additional health benefits.
Conclusion
While NAD+ boosting supplements may seem promising, the potential risks and lack of clear clinical benefits warrant caution, especially for individuals with specific health conditions. Instead, focusing on natural approaches, like regular exercise and a diet rich in flavonoids, can effectively enhance NAD+ levels and contribute to overall health.
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