RHR: The Melatonin Problem
Chris KresserPublished on September 29, 2026
Summary authored by editor@wellifi.com
TLDR Summary
This episode explores the complexities of melatonin use, emphasizing its role as a hormone that signals the body rather than a simple sleep aid. It raises concerns about long-term use, particularly among children, and suggests alternative approaches to improve sleep quality.
Key Points
- The effective dose of melatonin for sleep improvement is often much lower than commonly thought.
- Higher doses of melatonin can lead to daytime drowsiness and other effects.
- The quality control of melatonin supplements is questionable.
- The use of melatonin among children has surged, leading to increased emergency calls.
Understanding Melatonin: A Closer Look at Its Use and Potential Risks
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Introducing Fluid Motion
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The Rise of Melatonin Use
Hello everyone, this is Chris Kresser, and welcome to another episode of Revolution Health Radio. Today, we're diving into melatonin. Walk into any pharmacy, and you'll find an entire shelf filled with bottles, gummies, sprays, and chewable tablets of melatonin, with doses ranging from a fraction of a milligram to 10 or 20 milligrams. According to the CDC, sales of melatonin in the U.S. have nearly tripled between 2016 and 2020, with many people taking it nightly for years. Parents give it to their young children, and teenagers take it before exams. It has become the go-to solution for those struggling to sleep.
Melatonin: A Hormone, Not a Sleep Aid
My relationship with melatonin is complex. While I have recommended it in my practice for specific cases, I have growing concerns about its widespread use among both adults and children. A recent large observational study presented at the American Heart Association conference found that chronic insomnia patients using melatonin for a year or more faced nearly double the risk of heart failure compared to those who did not use it. This news sparked significant attention, and while it raised alarms, it also missed some critical details.
The biggest issue lies in the prevailing belief that melatonin, being a natural hormone produced by the body, must be harmless. This notion is misleading; hormones have powerful effects, and melatonin deserves the same respect as any other hormone.
What Does Melatonin Do?
Melatonin is primarily produced by the pineal gland and is largely controlled by light exposure. When light hits the retina, particularly blue light during the day, it sends a signal to the body’s biological clock, suppressing melatonin secretion. When darkness falls, this suppression ceases, and melatonin levels begin to rise, peaking around midnight before gradually declining as morning approaches. Thus, melatonin's role is not to put you to sleep but to inform every cell in your body about the time.
The Risks of Long-Term Use
As a hormone, melatonin has receptors throughout the body, including in the heart, blood vessels, pancreas, intestines, reproductive organs, and immune system. Therefore, when taken as a supplement, you are not just enhancing sleep but sending a hormonal signal to multiple tissues simultaneously, often at much higher doses than what the pineal gland produces naturally. This realization raises concerns, especially with children and adolescents.
Key Takeaways from Melatonin Research
- The effective dose of melatonin for sleep improvement is often much lower than commonly thought, with studies showing benefits with doses as low as 0.3 mg (300 mcg).
- Higher doses can lead to daytime drowsiness and other undesirable effects.
- The quality control of melatonin supplements is questionable, with products often containing either too little or too much of the hormone, and some containing unlisted ingredients like serotonin.
- The use of melatonin among children has surged, with reports of increased emergency calls related to accidental ingestion and adverse effects.
Alternatives and Recommendations
If you or your child is taking melatonin regularly, consider revisiting the basics of sleep hygiene. Factors such as light exposure, screen time, and consistent sleep schedules can significantly improve sleep quality without the need for hormonal supplements.
In my practice, I often recommend magnesium and specific herbal supplements to support relaxation and sleep quality. For instance, magnesium helps calm the nervous system, while herbs like ashwagandha and saffron have been shown to improve sleep quality and reduce stress.
Conclusion
In summary, melatonin is a potent hormone that signals the body when night falls. While it can be useful for short-term adjustments to biological clocks, using it nightly for years can mask underlying sleep issues and may not be as safe as we once thought. If you are using melatonin regularly, consider taking a break and allowing your body to regain its natural rhythm.
For more information on Fluid Motion and other health products, visit adaptnaturals.com.
Thank you for listening. For episode summaries and links to studies mentioned, visit ChrisKresser.com. Until next time, stay healthy!