Nattokinase: The Natural Enzyme for a Healthy Heart
Nattokinase is an enzyme extracted from natto, a traditional Japanese food made from fermented soybeans It has been widely studied for its beneficial effects on cardiovascular health, particularly in promoting healthy blood flow and maintaining blood pressure levels.
Supplement Summary
| Name | Nattokinase |
|---|---|
| Category | Enzymes |
| Main Uses |
|
| Effectiveness | High - numerous studies support its benefits for heart health |
| Common Dosage | 100-200 mg 1-2 times a day |
| Price Range | $-$$ |
| Forms Available | Capsules Powder |
Pros
- ✅ Supports cardiovascular health
- ✅ Promotes healthy blood flow
- ✅ May help in maintaining normal blood pressure
- ✅ Natural and safe
- ✅ Easy to incorporate in the diet
Cons / Side Effects
- ❌ Mild stomach upset in some individuals
- ❌ Risk of bleeding if taken with blood-thinning medication
- ❌ Not suitable for those with soy allergies
- ❌ Requires medical consultation if you have a bleeding disorder
What Is Nattokinase?
Nattokinase is an enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. It has been widely studied for its beneficial effects on cardiovascular health, particularly in promoting healthy blood flow and maintaining blood pressure levels.
How It Works
Nattokinase works by breaking down fibrin, a protein that can lead to blood clotting and plaque buildup in the arteries. This fibrinolytic activity is what makes Nattokinase beneficial for cardiovascular health.
Who It's Best For
Nattokinase is best for individuals looking to support their cardiovascular health, particularly those wanting to maintain healthy blood pressure and blood flow.
Who Should Avoid It
People on blood-thinning medication, those with bleeding disorders, and individuals with soy allergies should avoid Nattokinase.
Dosage & Usage Tips
The typical dosage for Nattokinase is 100-200 mg, taken 1-2 times a day on an empty stomach. Always consult with your healthcare provider before starting any new supplement regimen.
Buying Advice & Quality Tips
When buying Nattokinase, look for supplements that are non-GMO and free of unnecessary fillers. Check for products that specify the enzyme activity units (FU) to ensure potency.
Price & Value
While the price of Nattokinase can vary, it is generally considered a cost-effective option for maintaining cardiovascular health when compared to other supplements and medications.
Final Verdict
Nattokinase is a safe, natural supplement with potential cardiovascular benefits. However, as with any supplement, it's vital to consult with a healthcare provider before starting a regimen.
Additional Clinical Research
Here are three published scientific studies specifically investigating the effects of nattokinase:
RESEARCH SUMMARY: Nattokinase
KEY FINDINGS:
Blood Pressure Reduction
- Nattokinase supplementation resulted in a significant reduction in both systolic and diastolic blood pressure among subjects with pre-hypertension or stage 1 hypertension.
- Study details: Randomized, double-blind, placebo-controlled trial with 86 participants aged 20 to 80 years; intervention lasted 8 weeks.
Source: Kim et al. (2008)
View Research
https://pubmed.ncbi.nlm.nih.gov/18971533/
Antithrombotic Effects
- A single dose of nattokinase enhanced fibrinolysis and anticoagulation profiles, indicated by increased D-dimer levels and prolonged activated partial thromboplastin time.
- Study details: Double-blind, placebo-controlled crossover study with 12 healthy young males; assessed coagulation parameters over 8 hours post-administration.
Source: Kurosawa et al. (2015)
View Research
https://pubmed.ncbi.nlm.nih.gov/26109079/
Cardiovascular Risk Reduction
- Consumption of nattokinase was associated with reduced blood pressure and decreased levels of von Willebrand factor, a cardiovascular risk marker.
- Study details: Randomized, double-blind, placebo-controlled, multicenter trial with 79 subjects; intervention lasted 8 weeks.
Source: Jensen et al. (2016)
View Research
https://pubmed.ncbi.nlm.nih.gov/27785095/
RESEARCH QUALITY ASSESSMENT:
- All studies were randomized, controlled trials, enhancing the reliability of the findings.
- Sample sizes varied, with some studies having relatively small cohorts, which may limit generalizability.
- Short intervention durations in some studies may not capture long-term effects of nattokinase supplementation.
- Further large-scale, long-term studies are needed to confirm these findings and elucidate the mechanisms of action.